View abstract. J Altern Complement Med 2002;8(5):567-572. Memorial Sloan Kettering was founded in 1884, and today is a world leader in patient care, research, and educational programs. View abstract. Kimura, Y., Okuda, H., and Ogita, Z. Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell. View abstract. Pharmacist's Letter/Prescriber's Letter. 2021 Mar;10(3):2979-2989. [Clinical and experimental study on inhibitory effect of sanhuang mixture on platelet aggregation]. J Hazard.Mater. Our highly-specialized educational programs shape leaders to be at the forefront of cancer care and research. Phytomedicine. Z., Wang, Y., and Liu, B. Baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis in vitro and in vivo. J Med Food 2007;10:442-51. View abstract. Zhou, J., Qu, F., Zhang, H. J., Zhuge, X. H., and Cheng, L. Z. Anesth Analg 2003;97:1724-9. But there is not enough information to know if Baikal skullcap is the cause of these side effects. 2010;17(10):760-770. View abstract. Chem Pharm Bull (Tokyo) 1992;40(2):531-533. View abstract. Zhang, D. Y., Wu, J., Ye, F., Xue, L., Jiang, S., Yi, J., Zhang, W., Wei, H., Sung, M., Wang, W., and Li, X. Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. Mu, R., Qi, Q., Gu, H., Wang, J., Yang, Y., Rong, J., Liu, W., Lu, N., You, Q., and Guo, Q. View abstract. WebScutellaria baicalensis, a medicinal herb belonging to the Lamiaceae family, has been recorded in the Chinese, European, and British Pharmacopoeias. View abstract. Yuan Y., Liu Y.J, Luo Y.J, and et al. 2013;140:22-30. 1999;385-6, 400-1. Ann Palliat Med. Contact Dermatitis. Levy RM, Saikovsky R, Shmidt E, et al. Baumann, S., Fas, S. C., Giaisi, M., Muller, W. W., Merling, A., Gulow, K., Edler, L., Krammer, P. H., and Li-Weber, M. Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis. Keep in mind that natural products are not always necessarily safe and dosages can be important. Ye, F., Wu, J., Dunn, T., Yi, J., Tong, X., and Zhang, D. Inhibition of cyclooxygenase-2 activity in head and neck cancer cells by genistein. Yin, F., Liu, J., Ji, X., Wang, Y., Zidichouski, J., and Zhang, J. Baicalin prevents the production of hydrogen peroxide and oxidative stress induced by Abeta aggregation in SH-SY5Y cells. Check your mobile for SMS (Didn't get the message, repeat Step 1). Some medications are moved in and out of cells by pumps. Altern.Ther.Health Med. 5. It might cause drowsiness. Taking Baikal skullcap might decrease how well the body gets rid of lithium. View abstract. An herbal supplement containing S. baicalensis reduced symptoms of osteoarthritis(22). Vopr.Onkol. Kim, D. S., Son, E. J., Kim, M., Heo, Y. M., Nam, J. View abstract. Vopr.Onkol. J Nat Prod 1998;61:1413-5. Anticancer Res 2007;27(1A):117-125. Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others. View abstract. J Nat Prod 1997;60(6):598-601. Chen, H. H., Hong, H. J., Chou, Y. H., Cheng, T. H., Chen, J. J., and Lin, H. Inhibition of cyclic strain-induced endothelin-1 secretion by baicalein in human umbilical vein endothelial cells. Taking Baikal skullcap along with some medications that are changed by the liver might increase the effects and side effects of some medications. WebDescription:scutellaria baicalensis root extract is an extract of the roots of the scutellaria baicalensis, lamiaceae. Animal models also suggest antitumor activity with S. barbata across a range of cancers(16)(17)(18)(19)(20). Ann Intern Med 2012;156:894-5. Monitor your blood sugar closely. 6-29-2011; View abstract. Jianjun, J. and Huiru, D. Preparation of high-purity baicalein from Scutellaria baicalensis Georgi. Cancer Lett. 12-10-2008;8(12):1652-1657. Here we will discuss the most prominent benefits of the medicine. View abstract. View abstract. Bioorg.Med Chem 8-1-2008;16(15):7516-7524. View abstract. Chang, W. H., Chen, C. H., and Lu, F. J. View abstract. Zhu, G., Li, C., and Cao, Z. Inhibitory effect of flavonoid baicalin on degranulation of human polymorphonuclear leukocytes induced by interleukin-8: potential role in periodontal diseases. View abstract. Toxicology 5-2-2009;259(1-2):10-17. 2011;39(1):217-224. Front Biosci. Chinese journal of modern developments in traditional medicine 1990;10(5):278-9. 2010;16(2):32-40. Li BQ, Fu T, Gong WH, et al. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. View abstract. Not enough is known about the safety of Baikal skullcap in children when used long-term. Phytother.Res 2003;17(6):640-644. Razina, T. G., Zueva, E. P., Litvinenko, V. I., and Kovalev, I. P. [A semisynthetic flavonoid from the Baikal skullcap (Scutellaria baicalensis) as an agent to enhance the efficacy of chemotherapy in experimental tumors]. View abstract. It often is used in combination with other botanicals such as PC-SPES and sho-saiko-to. Kim, B. R., Kim, D. H., Park, R., Kwon, K. B., Ryu, D. G., Kim, Y. C., Kim, N. Y., Jeong, S., Kang, B. K., and Kim, K. S. Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes. Himeji, M., Ohtsuki, T., Fukazawa, H., Tanaka, M., Yazaki, S., Ui, S., Nishio, K., Yamamoto, H., Tasaka, K., and Mimura, A. View abstract. View abstract. Low blood pressure: Baikal skullcap might lower blood pressure. View abstract. Successful treatment of pediatric psoriasis with Indigo naturalis composite ointment. Chemicals in skullcap might cause sleepiness. New York, NY: CRC Press LLC. View abstract. Scheck, A. C., Perry, K., Hank, N. C., and Clark, W. D. Anticancer activity of extracts derived from the mature roots of Scutellaria baicalensis on human malignant brain tumor cells. Scutellaria Baicalensis ( Baical Skullcap ) is a plant. View abstract. Scutellaria baicalensis root: Uses, Interactions, Mechanism of Action | DrugBank Online Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locator Tool Including 24 Hour, Pharmacies. Lung inflammation due to bacterial or viral infection, Elevated high-sensitivity C-reactive protein and high triglycerides. Baicalin is anti-inflammatory in cigarette smoke-induced inflammatory models in vivo and in vitro: A possible role for HDAC2 activity. View abstract. View abstract. Side effects are few and may include drowsiness. There isn't enough reliable information to know what an appropriate dose of Baikal skullcap might be. 2008;6(1):103-8. Zhang CZ, Wang SX, Zhang Y, et al. View abstract. Baikal skullcap might lower blood pressure. Huang KC. Scutellaria baicalensis is a very well-known anti-inflammatory agent widely used in oriental medicine. Zhang, D. Y., Wu, J., Ye, F., Xue, L., Jiang, S., Yi, J., Zhang, W., Wei, H., Sung, M., Wang, W., and Li, X. Inhibition of cancer cell proliferation and prostaglandin E2 synthesis by Scutellaria baicalensis. Neurosci Lett. 1997;11(3):125-131. Pharmacol Biochem Behav 2009;92(4):642-648. View abstract. Lin, A. M., Ping, Y. H., Chang, G. F., Wang, J. Y., Chiu, J. H., Kuo, C. D., and Chi, C. W. Neuroprotective effect of oral S/B remedy (Scutellaria baicalensis Georgi and Bupleurum scorzonerifolfium Willd) on iron-induced neurodegeneration in the nigrostriatal dopaminergic system of rat brain. Therapeutic effect of Scutellaria baicalensis on L-thyroxine-induced hyperthyroidism rats. View abstract. Planta Med 2001;67(5):396-399. View abstract. Health-related information changes frequently and therefore information contained on this Web site may be outdated, incomplete or incorrect. J Pharm Pharmacol 1997;49(8):816-822. 2000;23(5):272-274. View abstract. Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root. 2008;8(3):264-268. Li, H. N., Nie, F. F., Liu, W., Dai, Q. S., Lu, N., Qi, Q., Li, Z. Y., You, Q. D., and Guo, Q. L. Apoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo. Himeji, M., Ohtsuki, T., Fukazawa, H., Tanaka, M., Yazaki, S., Ui, S., Nishio, K., Yamamoto, H., Tasaka, K., and Mimura, A. The root is used to make medicine. Stop using Baikal skullcap at least 2 weeks before a scheduled surgery. Yim, J. S., Kim, Y. S., Moon, S. K., Cho, K. H., Bae, H. S., Kim, J. J., Park, E. K., and Kim, D. H. Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora. Phytother.Res 2009;23(10):1415-1420. Sichuan.Da.Xue.Xue.Bao.Yi.Xue.Ban. Baikal skullcap is POSSIBLY SAFE for most adults when taken by mouth. Zhang CZ, Wang SX, Zhang Y, et al. Planta Med 2010;76(7):678-682. Baikal skullcap might have some of the same effects as estrogen. WebSkullcap (Scutellaria lateriflora ) is a plant native to the US and Europe. View abstract. Information from this source is evidence-based and objective, and without commercial influence. Dry extract of Scutellaria baicalensis as a hemostimulant in antineoplastic chemotherapy in patients with lung cancer. J Dent Res 1982;61(9):1103-1106. Che, Q. M., Huang, X. L., Li, Y. M., Kun, Z., Teruaki, A., and Masao, H. [Studies on metabolites of baicalin in human urine]. View abstract. View abstract. However, different extraction methodologies and/or plant origins have yielded varying degrees of antitumor effects(21). Wang, G. F., Wu, Z. F., Wan, L., Wang, Q. T., and Chen, F. M. Influence of baicalin on the expression of receptor activator of nuclear factor-kappaB ligand in cultured human periodontal ligament cells. Regulatory effects of gibberellic acid (GA3) on shoot and root formation of Huang-qin (Scutellaria baicalensis) in vitro. Intern Med 2001;40:764-8. Chang, H. H., Yi, P. L., Cheng, C. H., Lu, C. Y., Hsiao, Y. T., Tsai, Y. F., Li, C. L., and Chang, F. C. Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. Scutellaria baicalensisis used in traditional medicine to treat many medical conditions, but studies in humans are limited.S. Pasanen MK, Fredrikson H, Neuvonen PJ, Niemi M. Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin. Med Hypotheses. Song, S. J., Li, F. F., Xu, Y., Zhang, L. H., Yuan, F., and Zhang, Y. Enomoto, R., Koshiba, C., Suzuki, C., and Lee, E. Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. It is used with other herbs in traditional Chinese medicine to treat bacterial infections, hepatitis, and tumors. Mol Nutr Food Res 2008;52(11):1349-1357. Ceska.Slov.Farm. WebMD does not provide medical advice, diagnosis or treatment. Morgan SL, Baggott JE, Morel, L, Desmond R, and Kendrach AC. View abstract. CNS.Neurol.Disord Drug Targets. View abstract. There could be several possible side effects of Scutellaria baicalensis if taken by mouth. T View abstract. Tarrago, T., Kichik, N., Claasen, B., Prades, R., Teixido, M., and Giralt, E. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. J Ethnopharmacol. View abstract. J Cell Biochem 10-1-2010;111(2):274-283. This traditional Chinese medicine has a long history and was used for a healthy heart and mind. Guo, H. X., Liu, D. H., Ma, Y., Liu, J. F., Wang, Y., Du, Z. Y., Wang, X., Shen, J. K., and Peng, H. L. Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet. December 19, 2017. Acta Pharmacol Sin. Leuk.Res 2007;31(4):523-530. Inhibitory effects of wogonin on catalytic activity of cytochrome P450 enzyme in human liver microsomes. There are a number of different names that people use for Baicalin. Vopr.Onkol. 1-19-2007;109(2):325-330. Drug Metab Dispos 2005;33:537-46. View abstract. Tsao, T. F., Newman, M. G., Kwok, Y. Y., and Horikoshi, A. K. Effect of Chinese and western antimicrobial agents on selected oral bacteria. 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