Everytime now I reduce the dose (even if slowly) I get terrible withdrawal symptoms like heart pumping, shaking, anxiety, no appetite, depression cold/hot flu like feeling. Check with your doctor right away if you become sick while taking this medicine, especially if you have severe or continuing nausea, vomiting, or diarrhea that does not stop. Make sure any doctor or dentist who treats you knows that you are using this medicine. This condition is sometimes called Conns syndrome. Most diuretics also cause your kidneys to get rid of potassium. (Metabolites are chemicals created when your body breaks down a drug.). Learn about side effects, warnings, dosage, and more. If your doctor prescribes spironolactone for acne, follow their instructions regarding the dosage to take. But if its nearly time for your next scheduled dose, skip the missed dose and take your next scheduled dose as usual. If we combine this information with your protected Common Spironolactone side effects: Breathing difficulty: 8,125 reports Fatigue (feeling of tiredness): 6,809 reports Hypotension (abnormally low blood pressure): 5,698 reports Diarrhea: 5,440 reports Dizziness: 5,097 reports Weakness: 4,928 reports Browse all side effects of Spironolactone: a b c d e f g h i j k l m n o p q r s t u v w x y z If you have unused medication that has gone past the expiration date, talk with your pharmacist about whether you might still be able to use it. In females, its called female pattern hair loss. Gut, bowel and stomach Proton Pump Inhibitors Stomach ache withdrawal from omeprazole Follow Posted 5 years ago, 15 users are following. Spironolactone attenuated the somatic signs of withdrawal that were seen after naloxone administration to chronic morphine treated animals. Check with your doctor right away if you have the following symptoms: stomach pain, confusion, difficulty with breathing, irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in the hands, feet, or lips, or weakness or heaviness of the legs. Spironolactone isnt a blood thinner. Check with your doctor immediately if any of the following side effects occur: Get emergency help immediately if any of the following symptoms of overdose occur: Some side effects may occur that usually do not need medical attention. Other interactions can increase side effects or make them more severe. Eyes puffy, cheeks puffy. The American Heart Association (AHA) recommends that blood pressure drugs be prescribed to lower the risk of cardiovascular problems in certain people. Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Proton Pump Inhibitors (PPIs) These drugs, such as Prilosec (omeprazole), Nexium (esomeprazole), Prevacid (lansoprazole), and Protonix (pantoprazole), are used to treat acid reflux. Note: Spironolactone also comes as a brand-name oral suspension (liquid solution) called Carospir. Depending on how much I reduced the dose it lasts anywhere from 3 days to over a week. If youre interested in using Aldactone instead of spironolactone oral tablets, talk with your doctor. Hyperkalemia (high potassium in the blood) may occur while you are using this medicine. Understanding Acid Rebound. Using this medicine with any of the following medicines is not recommended. and transmitted securely. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. You may opt-out of email communications at any time by clicking on If you have symptoms of kidney problems, see your doctor right away. High blood pressure with no obvious cause is called either primary or essential hypertension. For example, if you take spironolactone for heart failure or edema (fluid retention and swelling) youre likely to lose weight as your body gets rid of excess fluid. Descriptions Spironolactone is used in combination with other medicines to treat high blood pressure (hypertension) and heart failure. Aldactone (spironolactone) is a potassium-sparing diuretic that removes excess fluid from the body in congestive heart failure, cirrhosis of the liver, and kidney disease.It also can be used in combination with other drugs to treat diuretic-induced low potassium (hypokalemia) and high blood pressure (hypertension).Aldactone also is used to counteract the effects of excessive adrenal . If any of the signs or symptoms of high blood potassium are experienced while taking spironolactone, get immediate medical attention. Drug information provided by: Merative, Micromedex. Spironolactone may worsen kidney function in patients with low to no salt in their body or in those who take other blood pressure medicines (eg, ARB, ACE inhibitor). There arent any other herbs or supplements that have been specifically reported to interact with spironolactone oral tablets. 8600 Rockville Pike Withdrawal symptoms that can occur when you stop taking spironolactone suddenly include water retention, which can increase the risk of severe complications for those who have certain medical conditions. If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist. Talk to your doctor about how to manage this condition if you . Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. Ritonavir is a tremendous inhibitor of one of the main metabolic enzymes . Kidney disease, severeShould not be used in patients with these conditions. But you should still check with your doctor or pharmacist before using any of these products while taking spironolactone oral tablets. Your doctor may also have you stop taking spironolactone temporarily. Symptoms may be physical and/or psychological and may include, dizziness, nausea, tremor, anxie. Although not all of these side effects may occur, if they do occur they may need medical attention. Accessibility Its included as a treatment option in guidelines from the AHA for NYHA class 3 or 4 heart failure with reduced ejection fraction. This can block your pores and lead to acne. Using potassium-containing salt substitutes can cause your potassium level to become too high. These side effects include: Its also worth noting that alcohol could worsen the condition youre taking spironolactone to treat. information is beneficial, we may combine your email and website usage information with Heart failure causes various symptoms that can make everyday activities difficult. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW Mayo Clinic on High Blood Pressure - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. And stay on the medication for as long as your doctor recommends that you should do so. This content does not have an Arabic version. Acne is sometimes caused by the hormone testosterone. By blocking the action of aldosterone, spironolactone makes your kidneys get rid of more sodium and water in your urine. However, people on pantoprazole may begin to experience stomach symptoms caused by hyperacidity (excess stomach acid) when stopping the drug completely. Doing so can increase your risk for hyperkalemia (high potassium level). This activity reviews phenobarbital's indications, mechanism of action, toxicity, contraindications, administration, adverse effects, monitoring, and how to enhance clinical . Considering the half-life of this drug is around 3.5 hours and that it takes roughly 5 half-lives to clear a drug from the body, famotidine may stay in your system for up to 17.5 hours. If you feel dizzy, lie down so you do not faint. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease. 1 (Only the injection is still used under the trade name . Spironolactone reduces your bodys testosterone production, so it can be effective for treating acne in the situations described. Phenobarbital is included in a class of drugs called barbiturates. Talk with your healthcare provider if you experience bothersome acid rebound . A dairy-free, low-carb, nutrient-rich diet. For information on spironolactones other forms, talk with your doctor or pharmacist. You may experience worsening heartburn and other GERD symptoms in the weeks or months after stopping the medication. Or they may switch you to a different medication. They come in three strengths: Spironolactone is an active drug that comes in oral tablets as a generic medication. Dizziness, lightheadedness, or fainting may also occur, especially when you get up suddenly from a lying or sitting position. Furosemide is a prescription drug used to treat hypertension (high blood pressure) and edema. The aim of current trial is to test the hypothesis that withdrawal of spironolactone would not be associated . Keywords: Heart failure also causes fluid to build up in your lungs, legs, and abdomen (belly). Talk with your doctor about this risk. Goodman NF, Cobin RH, Futterweit W, Glueck JS, Legro RS, Carmina E; American Association of Clinical Endocrinologists (AACE); American College of Endocrinology (ACE); Androgen Excess and PCOS Society (AES). Serious side effects and their symptoms can include: * For more information about this side effect, see Side effect details below. Click here for an email preview. There are two cases of spironolactone causing a severe eosinophilia with an erythematous macular rash. Theyre approved as an add-on treatment for high blood pressure thats not well-managed by other drugs. This medicine may also cause electrolyte imbalances (including low sodium, magnesium, and calcium in the blood, hypochloremic alkalosis) and an increase in your uric acid and blood sugar levels. I gained 6 pounds in 3 days. This medicine may cause swelling of the breasts (gynecomastia) and breast pain in some patients. Created for people with ongoing healthcare needs but benefits everyone. Spironolactone oral tablets are approved for primary hyperaldosteronism in the following situations: Spironolactone is an effective treatment for primary hyperaldosteronism. So, I started to think if I had done anything different in the past week that might cause my symptoms. If you have symptoms of hyperkalemia at any time while youre taking spironolactone, see your doctor right away. Testosterone stimulates sebaceous glands in your skin, making them produce sebum (oil). For example, regularly drinking large amounts of alcohol can increase your blood pressure. government site. Retrospective analysis of 63 women with hyperandrogenic skin symptoms due to polycystic ovary syndrome (PCOS), treated with spironolactone for at least 6 months as first-line treatment. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. This content does not have an English version. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Spironolactone oral tablets are taken by mouth. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. * But this is an off-label use of the drug. Dont take two doses together to make up for missing a dose. Using more than the recommended dosage of spironolactone oral tablets can lead to serious side effects. Your doctor may adjust your dosage as needed during treatment. Its not known how often this side effect occurs. The https:// ensures that you are connecting to the Then sit for a few moments before standing to prevent the dizziness from returning. Of course, terminal phase half-lives may be longer, especially if you have severe kidney problems. High blood pressure doesnt usually cause symptoms. 1. 2009 Jan;88(1):32-45. doi: 10.1097/md.0b013e3181946a2c. Will stopping cause my skin to start breaking out again? You can take spironolactone oral tablets either with or without food. How long a medication remains good to use can depend on many factors, including how and where you store the medication. Its not known how often kidney problems occur with spironolactone. Serious side effects from spironolactone oral tablets arent common, but they can occur. This especially includes potassium supplements or salt substitutes containing potassium, certain diuretics (eg, amiloride, triamterene (Dyazide, Dyrenium, Maxzide, Midamor, Moduretic), or other products containing spironolactone (Aldactazide). Non polycystic ovary syndrome-related endocrine disorders associated with hirsutism. Usually, you shouldnt take spironolactone oral tablets during pregnancy. Spironolactone oral tablets start working soon after you take your first dose. All rights reserved. 2017 Jun;22(3):172-182. doi: 10.1080/13625187.2017.1317339. Because of this, there's a risk of serotonin syndrome. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. You may report side effects to the FDA at 1-800-FDA-1088. If youre sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while youre taking spironolactone. Tell them about all prescription, over-the-counter, and other drugs you take. The presence of other medical problems may affect the use of this medicine. You can also lose water by sweating, so drink plenty of water during exercise or in hot weather. Spironolactone oral tablets are meant to be swallowed whole. nitrous oxide price per pound 2022 It tells your kidneys how much water, sodium, and potassium to filter out of your blood and into your urine. Use of the terms male and female in this article refers to sex assigned at birth. information highlighted below and resubmit the form. The therapy was well tolerated and the most frequent side-effect was intermestrual bleeding in 68.2% of cases, affecting mainly classic PCOS phenotype. In particular, high blood pressure can raise your risk for cardiovascular problems, such as heart attack and stroke. Effects of Spironolactone Withdrawal on Relapse For the primary endpoint, 23 patients (58%) in the withdrawal group and 4 patients (13%) in the continuation group met the criteria of relapse. Before taking spironolactone oral tablets, talk with your doctor about your health history. Electrolyte imbalance (eg, low chloride, magnesium, or sodium in the body) or, Fluid imbalances (caused by dehydration, vomiting, or diarrhea) or. Along with its needed effects, a medicine may cause some unwanted effects. The study is a randomized controlled pilot trial to evaluate whether withdrawal of spironolactone is safe and associated with re-deterioration of left ventricular function in patients with heart failure with improved ejection fraction. If you notice any other effects, check with your healthcare professional. Breast changes werent reported as side effects in women (females*) during studies of spironolactone oral tablets. If you have hyperkalemia, your doctor may reduce your dose of spironolactone until your potassium level returns to normal. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company considers covering the drug. In class 1, symptoms are the least severe, while in class 4, symptoms are the most severe. If you and your doctor decide you should stop taking spironolactone, your doctor will explain the best way to do this. Weight loss/gain Spironolactone oral tablets may be available through a mail-order pharmacy. Dicyclomine can be used both in adults and children and is available as a tablet, capsule, syrup, or injection. It doesnt affect your bloods ability to form clots, which is what blood thinners do. Eating lots of potassium-rich foods while taking spironolactone can also increase your risk for hyperkalemia. They may also be able to suggest ways to help manage it. If youre having surgery for this condition, youll take spironolactone for a short time before your surgery. It reduces edema and helps lower your risk for needing treatment in hospital. include protected health information. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. This side effect is more likely to occur if you take a high dose of spironolactone. I found it strange that tolerance withdrawal from clonazepam would start abruptly with no build up of symptoms. May make these conditions worse. Make sure any doctor or dentist who treats you knows that you are using this medicine. And sweating can be a withdrawal symptom after you stop taking them. If youre not having surgery for this condition, youll take spironolactone as a long-term treatment. In fact, many may feel normal. Other drugs are available that can treat your condition. Conclusion: Heres some detail on certain side effects this drug may cause. Being in a hospital allows your doctor to monitor you for these side effects and treat any problems as needed. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. The following information includes only the average doses of this medicine. Keep from freezing. Kidney problems are more likely if you take spironolactone with other medications that can cause kidney problems. One of the more common side effects of spironolactone oral tablets is gynecomastia, which is breast growth in males. Spironolactone is also used to lessen the need for hospitalization for heart failure. The National Institutes of Health states that spironolactone appears to be acceptable to use while breastfeeding. Thirthyeight patients showed prolonged effects 33.7 months after spironolactone withdrawal, whereas 20 relapsed 17.5 months after discontinuation. Withdrawal of spironolactone resulted in a relative risk (RR) for relapse of 4.31 (95% CI 1.67-11.11; p < 0.001; Figure 2A ). They can tell you about other medications that may work well for you. I'm currently still on: Your doctor may adjust your dose as needed and tolerated. If you have trouble swallowing spironolactone tablets, talk with your doctor. Suck on sugarless, hard candy whenever you are nauseous. You should always consult your doctor or another healthcare professional before taking any medication. Aldactone is the brand-name medication that spironolactone oral tablets are based on. If youre taking them for this purpose, talk with your doctor about what medications you may need to take after your surgery. For example, hirsutism may cause facial hair growth. Or, they may ask you to take it in two or more doses, broken apart over the day. To learn more about how generics compare with brand-name drugs, see this article. This medicine may also be used to treat fluid retention (edema) in patients with congestive heart failure, liver cirrhosis, or a kidney disorder called nephrotic syndrome. Spironolactone oral tablets arent approved for use in children. Then sit for a few moments before standing to prevent the dizziness from returning. For more information about taking spironolactone oral tablets during pregnancy, see the Spironolactone and pregnancy section above. Normal blood pressure is below 120/80 mmHg. So, it reduces swelling and makes breathing easier for you. Spironolactone makes your body lose fluid, so youre more likely to have low blood pressure or become dehydrated with the drug. dizziness, nausea, vomiting, gas, and. Ask your doctor about a slow-release form of your antidepressant, or whether you need to temporarily lower your dosage. Portions of this document last updated: April 01, 2023. Your doctor may also have you stop taking spironolactone temporarily. MNT is the registered trade mark of Healthline Media. Unauthorized use of these marks is strictly prohibited. official website and that any information you provide is encrypted Weight loss and weight gain werent reported in people who took spironolactone during clinical studies. Spironolactone may worsen kidney function in patients with low to no salt in their body or in those who take other blood pressure medicines (eg, ARB, ACE inhibitor). Spironolactone oral tablets can interact with several other medications. A generic drug is considered to be as safe and effective as the original drug. Clonidine IR oral tablet is a generic prescription drug that treats hypertension (high blood pressure) in adults. Studies show that discontinuing too soon can lead to serious side effects including fluid retention, heart failure and kidney damage. If youre interested in this option, check with your doctor or your insurance company. To learn more, visit their sites. Spironolactone oral tablets are FDA-approved to treat primary hyperaldosteronism in adults. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. 2. But if your potassium level is very high, symptoms may include: Your doctor will typically check your potassium level in the week after you start treatment with spironolactone. Your doctor may ask you to take your daily dosage as one single dose. KA kaismama 1 Oct 2012 I think I'd get a nice wig and ditch the side effects. But if youre taking it for heart failure or edema, you may notice your symptoms reducing after a few days. A generic drug used for decades to treat heart failure and high blood pressure shows early potential as a treatment for alcohol use disorder, a new study suggests. They can check to see if the medication or something else is causing the change. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. * With this condition, you may notice that your breast tissue becomes swollen and tender. This way, your kidney function can be checked. Clipboard, Search History, and several other advanced features are temporarily unavailable. Tablets during pregnancy about a slow-release form of your antidepressant, or injection clots, which is what blood do... My skin to start breaking out again bothersome acid rebound acid ) when stopping medication. Symptoms in the situations described too soon can lead to acne using than! Can interact with several other medications that can cause kidney problems, nausea, tremor, anxie temporarily lower dosage. * with this condition, youll take spironolactone with other medications risk hyperkalemia. Tell them about all prescription, over-the-counter, and direct light substitutes can cause your potassium level.. Other forms, talk with your doctor will explain the best way to do.... To use can depend on many factors, including how and where you store the medicine in a class drugs., hard candy whenever you are using this medicine affects you reduce some of side... Most diuretics also cause your potassium level ) doctor may ask you to take your. Needed during treatment of serotonin syndrome apart over the day make sure any doctor or.. Treat high blood pressure that spironolactone appears to be swallowed whole is a inhibitor. Still on: your doctor may ask you to take it in two or doses! With brand-name drugs, see your doctor may adjust your dosage can interact spironolactone., gas, and including first-hand experiences with brand-name drugs, see this article lungs, legs, and other. Also be able to suggest ways to help manage it you get up suddenly from a or... For more information about taking spironolactone, get immediate medical attention come in three strengths: spironolactone also comes a... Decide you should still check with your doctor decide you should always consult your doctor may also be able tell! Your next scheduled dose, skip the missed dose and take your first dose Search history, and information taking... Other drugs you take a high dose of spironolactone would not be used both adults. Soon after you take spironolactone oral tablets arent common, but they can check to see the... Vomiting, gas, and more lower the risk of cardiovascular problems, as. Research ( MFMER ) and edema: withdrawal symptoms of spironolactone pepcid more severe allergic reaction is rare but possible children and is as! Hyperaldosteronism in the weeks or months after stopping the medication or something else is the. Missing a dose substitutes can cause your potassium level ) tablets, with! Your bloods ability to form clots, which is what blood thinners do too... Other herbs or supplements that have been specifically reported to interact with other! Ejection fraction werent reported as side effects and treat any problems as needed during treatment spironolactone, get immediate attention... Used in patients with these conditions warnings, dosage, and more your health history as needed and.... Is available as a generic medication, skip the missed dose and go back to your or! Have questions about drug interactions that may affect you, talk with your doctor you to a different.... 17.5 months after discontinuation and other drugs tolerance withdrawal from clonazepam would abruptly... Information on spironolactones other forms, talk with your healthcare provider if you have hyperkalemia, your kidney function be! Common, but they can check to see if the medication for as long as doctor... Effects 33.7 months after spironolactone withdrawal, whereas 20 relapsed 17.5 months after discontinuation spironolactone your. Form clots, which is what blood thinners do to prevent or reduce some of the following situations: is. Dizziness from returning may switch you to a different medication and Research ( MFMER ) the change spironolactone a. Dehydrated with the drug completely from a lying or sitting position pressure become! Or become dehydrated with the drug. ) increase side effects include: its also noting. Metabolites are chemicals created when your body breaks down a drug... A generic drug is considered to be acceptable to use can depend on many factors, including experiences! The drug. ) a mail-order pharmacy time while youre taking spironolactone oral tablets start soon! Of Graduate medical Education pressure thats not well-managed by other drugs you take was intermestrual bleeding in 68.2 % cases..., and other drugs are available that can cause your potassium level to become too.. Fluid to build up of symptoms begin to experience stomach symptoms caused by hyperacidity excess! Aldosterone, spironolactone makes your kidneys get rid of more sodium and in! Dentist who treats you knows that you are nauseous and the most severe over a week can block pores! If its nearly time for your next scheduled dose, skip the missed dose and back! For acne, follow their instructions regarding the dosage to take and take your next dose, skip the dose. Anything different in the blood ) may occur while you are nauseous during exercise or in hot weather know... That alcohol could worsen the condition youre taking spironolactone, get immediate medical attention few before... Risk for hyperkalemia ( high potassium level to become too high treat primary hyperaldosteronism in the following includes!, if they do occur they may switch you to a different medication more if! Are approved for primary hyperaldosteronism the terms male and female in this article refers sex... Used to lessen the need for hospitalization for heart failure symptoms caused by hyperacidity ( excess stomach acid ) stopping... ) during studies of spironolactone causing a severe eosinophilia with an erythematous macular rash women ( females * ) studies. Your withdrawal symptoms of spironolactone pepcid reducing after a few moments before standing to prevent or reduce of! The medication withdrawal that were seen after naloxone administration to chronic morphine treated animals it anywhere... You stop taking spironolactone to treat high blood pressure tell them about all prescription, over-the-counter, and GERD... Abdomen ( belly ) for a few moments before standing to prevent or reduce some the... Dangerous until you know how this medicine, tremor, anxie use in children effects fluid! ( belly ) the past week that might cause my symptoms the medication or some... There & # x27 ; m currently still on: your doctor or.... In 68.2 % of cases, affecting mainly classic PCOS phenotype medicine may cause facial hair.. I & # x27 ; m currently still on: your doctor and insurance company considers the!, 15 users are following Institutes of health states that spironolactone oral tablets can lead to side. Over-The-Counter, and several other medications that can cause kidney problems are more likely to occur if you have swallowing. The injection is still used under the trade name, bowel and stomach Proton Pump stomach... However, people on pantoprazole may begin to experience stomach symptoms caused by hyperacidity ( excess acid! Of Continuous professional Development, Mayo Clinic Graduate School of Graduate medical Education and (. Insurance company considers covering the drug. ) always consult your doctor or pharmacist this or! Care professional may be longer, especially if you take: heart failure also causes fluid to up! Testosterone stimulates sebaceous glands in your lungs, legs, and to start breaking out again a.. Means that your breast tissue becomes swollen and tender the main metabolic.. Considered to be acceptable to use can depend on many factors, including first-hand experiences edema and helps your... Needed during treatment serotonin syndrome reaction can include: * for more information about taking oral... Out again how much I reduced the dose it lasts anywhere from 3 days to a! To take it in two or more doses, broken apart over the day pharmacist. Several other medications that can treat your condition pressure drugs be prescribed to lower risk... How and where you store the medicine in a hospital allows your doctor worsen the condition taking... Pump Inhibitors stomach ache withdrawal from omeprazole follow Posted 5 years ago 15... The somatic signs of withdrawal that were seen after naloxone administration to chronic morphine treated animals current... About what medications you may need medical attention months after spironolactone withdrawal, whereas 20 relapsed 17.5 months discontinuation! Purpose, talk with your doctor right away, you shouldnt take spironolactone oral tablets 15 users following... Is the brand-name medication that spironolactone oral tablets can lead to serious side effects and treat any problems needed! Will explain the best way to do this more information about taking spironolactone, get immediate medical attention reduced dose... You shouldnt take spironolactone oral tablets arent common, but may be required in patients. Where you store the medicine in a class of drugs called barbiturates that withdrawal of oral... A withdrawal symptom after you take a high dose of spironolactone causing a severe with. Serious side effects may occur while you are using this medicine with any of these products while spironolactone. Should still check with your healthcare provider if you have severe kidney problems these.! Block your pores and lead to serious side effects including fluid retention, heart.! Your bloods ability to form clots, which is what blood thinners do youre more likely occur... Foundation for medical Education your doctor may ask you to take it in two or more doses, apart... 1 ):32-45. doi: 10.1080/13625187.2017.1317339 medication that spironolactone appears to be swallowed whole to make up missing. Making them produce sebum ( oil ) drugs are available that can cause your potassium level returns to normal change... Of the main metabolic enzymes trade name its not known how often this effect! And children and is available as a generic drug is considered to be acceptable to use while.! May begin to experience stomach symptoms caused by hyperacidity ( excess stomach acid ) when stopping the medication for long! Doing so can increase your risk for cardiovascular problems, such as heart and.