This chemical might increase serious side effects of some medications used for depression. The adverse effects associated with tianeptine are similar in many respects to those of the SSRIs and minimal in comparison with the tricyclic antidepressants. 1989 Mar;16(3):186-91 All rights reserved. [12] The same researchers subsequently found that the MOR is required for the acute and chronic antidepressant-like behavioral effects of tianeptine in mice and that its primary metabolite had similar activity as a MOR agonist but with a much longer elimination half-life. Primarily in the fact that it does not act immediately through regulation of monoaminergic neurotransmitters, such as noradrenaline, dopamine, and serotonin. [41], Research suggests that tianeptine produces its antidepressant effects through indirect alteration and inhibition of glutamate receptor activity (i.e., AMPA receptors and NMDA receptors) and release of BDNF, in turn affecting neural plasticity. A literature review conducted in 2018 found 25 articles involving 65 patients with tianeptine abuse or dependence. Tianeptine appears to be as effective as fluoxetine, sertraline, amitriptyline, clomipramine and mianserin and more effective than maprotiline in improving associated anxiety in patients with depressive disorders. It investigates factors that could create distress or effect quality of life. View abstract. However, considering the abuse potential, you should always ask yourself if you trust yourself to regulate your dosages. 681 of June 30, 1998 on the Approval of the List of Narcotic Drugs, Psychotropic Substances and Their Precursors That Shall Be Subject to Control in the Russian Federation (with Amendments and Additions)", "Michigan approves ban on antidepressant tianeptine sodium", "Public Health Code Section 333.7214.amended", "New crime trend in Giles Co. after Alabama stops selling ZaZa Red, controversial stimulant", "Governor DeWine Authorizes the State of Ohio Board of Pharmacy to Adopt Emergency Rule to Ban the Sale and Use of Tianeptine", Tianeptine David Pearce The Good Drug Guide, https://en.wikipedia.org/w/index.php?title=Tianeptine&oldid=1146332073. In consideration of the sale of the product to the purchaser, which sales we would not otherwise make, purchaser agrees to indemnify and hold NootropicSource harmless from all claims, expenses, losses and liability of any nature whatsoever arising out of purchasers handling and/or use of any product sold here, whether used alone or in combination with any other substance no matter what its origination. In terms of chemical structure, it is similar to tricyclic antidepressants (TCAs), but it has significantly different pharmacology and important structural differences, so it is not usually grouped with them. PMC Fans of the sulfate form often describe the effect as feeling smoother than Tianeptine sodium. Prim Care Companion CNS Disord. Some people may have difficulty stopping their use of tianeptine and may experience withdrawal symptoms. 6. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. This means that you can easily self-administer the substance after learning about it. Mirtazapine may cause a serious condition called serotonin syndrome if taken together with some medicines. [8] Tianeptine is usually packaged as a sodium salt but can also be found as tianeptine sulfate, a slower-releasing formulation patented by Janssen in 2012. Changes in neuroplasticity are directly linked to a reduction in depressive and stress-induced symptoms. Do not use mirtazapine with buspirone (Buspar), fentanyl (Abstral, Duragesic), lithium (Eskalith, Lithobid), tryptophan, St. John's wort, or some pain or migraine medicines (eg, rizatriptan, sumatriptan, tramadol, Frova, Imitrex, Maxalt, Relpax, Ultram, Zomig). Tianeptine contains a chemical that affects the body. MMWR Morb Mortal Wkly Rep. 2018;67(30):815-818. Vadachkoria D, Gabunia L, Gambashidze K, Pkhaladze N, Kuridze N. Addictive potential of Tianeptine - the threatening reality. Often the solution is not filtered well thus particles in the injected fluid block capillaries, leading to thrombosis and then severe necrosis. 1988;11 Suppl 2:S90-6. Parkinson's disease may be caused by low levels of a chemical called dopamine (DOE pa meen) in the brain. Key reasons to invest in air conditioning for your home. Tianeptine is available in two forms; sulfate and sodium. 2002;17 Suppl 3:331-40. Tianeptine is a tricyclic antidepressant used to treat depression in some European,. Neuroprotection Tianeptine, sold under the brand names Stablon and Coaxil among others, is an atypical tricyclic antidepressant which is used mainly in the treatment of major depressive disorder, although it may also be used to treat anxiety, asthma, and irritable bowel syndrome. El Zahran T, Schier J, Glidden E, et al. View abstract. View abstract. *BottlesGramsMilligrams. 1991;29(2):64-6. Alpha-GPC Guelfi JD, Dulcire C, Le Moine P, Tafani A. Return to Pill Identifier This contributes to users having to take larger dosages to achieve the same effects as before. [4] For unclear reasons development of tianeptine was discontinued in both countries in January 2012. Tianeptine is an opioid, and opioids have anti-anxiety (anxiolytic) effects Unlike benzodiazepines, Tianeptine is non-impairing Tianeptine reverses stress-induced changes in the brain that may hinder social cognition Anecdotal reports about the use if tianeptine for SA have been favorable Tianeptine Risks There are some disadvantages to tianeptine. Multi ingredient medications may also be listed when applicable. The .gov means its official. Bence C, Bonord A, Rebillard C, et al. Routes of intake included oral, intravenous, and insufflation entry. [24] By November 2004, there had been two double-blind placebo-controlled crossover trials and an under-25,000 person open-label study lasting over seven years, both showing effectiveness. Poison control center experience with tianeptine: an unregulated pharmaceutical product with potential for abuse. Interestingly, while tianeptine also produces many opiate-like behavioral effects such as analgesia and reward, it does not lead to tolerance or withdrawal. Zaza is def sulfate. Kasper S, Praschak-Rieder N, Tauscher J, Wolf R. Drug Saf. I had expected this based on the chemical properties of tianeptine. Send Inquiry. Information from this source is evidence-based and objective, and without commercial influence. [27], Known contraindications include the following:[28], Compared to other tricyclic antidepressants, it produces significantly fewer cardiovascular, anticholinergic (like dry mouth or constipation), sedative and appetite-stimulating effects. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. 2018;56(11):1155-1158. Although other countries have approved tianeptine to treat depression and anxiety, some have restricted how tianeptine is prescribed or dispensed, or revised the drug label to warn of possible addiction. If you are experiencing depression, we strongly recommend that you first speak to your doctor about your treatment options, which will ideally involve a combination of talk therapy and medication. That could make it especially risky for overdoses. MeSH 2018;20(4). However, the severity will increase with the length of usage and quantity. Tianeptine is an unapproved drug in the U.S. Samuels BA, Nautiyal KM, Kruegel AC, et al. Weve provided information in this article that will help you decide which form of Tianeptine is right for you. HHS Vulnerability Disclosure, Help Buy the best Nootropics online from Nootropic Source Today! Stablon/Coaxil, also known as Tianeptine is a pharmaceutical-grade compound that is often used for the treatment of clinical depression. [15] It was shown to be more effective than maprotiline in a group of people with co-existing depression and anxiety. Sohn W, Lee OY, Kwon JG, et al. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Customer represents and warrants to us that from customers own independent review and study they are fully aware and knowledgeable about (I) the health and safety hazards associated with the handling of the products purchased; (II) industrial hygiene controls necessary to protect its workers from such health and safety hazards; (III) the need to adequately warn of health and safety hazards associated with products; and (IV) government regulations regarding the use of and exposure to such products. [7] Tianeptine also displays significant anxiolytic properties and is useful in treating a spectrum of anxiety disorders including panic disorder, as evidenced by a study in which those administered 35% CO2 gas (carbogen) on paroxetine or tianeptine therapy showed equivalent panic-blocking effects. Acute Toxicity From Intravenous Use of the Tricyclic Antidepressant Tianeptine. Drugs. This may be achieved by regulating the excitatory amino acid systems that are responsible for changes in the strength of synaptic connections as well as enhancing BDNF expression, although these findings are based largely on preclinical studies. Tianeptine, sold under the brand names Stablon and Coaxil among others, is an atypical tricyclic antidepressant which is used mainly in the treatment of major depressive disorder, although it may also be used to treat anxiety, asthma, and irritable bowel syndrome. On March 13, 2020, with a decree approved by the Minister of Health, Italy became the first European country to ban tianeptine considering it a Class I controlled substance. It is an atypical antidepressant used in Europe to treat patients who respond poorly to selective serotonin reuptake inhibitors (SSRIs). 2022 Jul;239(7):2187-2199. doi: 10.1007/s00213-022-06093-w. Epub 2022 Feb 24. [17] Like many antidepressants (including bupropion, the selective serotonin reuptake inhibitors, the serotonin-norepinephrine reuptake inhibitors, moclobemide and numerous others) it may also have a beneficial effect on cognition in people with depression-induced cognitive dysfunction. The FDA has taken steps to protect people from unapproved tianeptine products, including warning consumers that tianeptine is an unsafe food additive and not a dietary ingredient. Tianeptine modestly enhances the mesolimbic release of dopamine[50] and potentiates CNS D2 and D3 receptors. It's being marketed as a dietary supplement, but some users are describing it as a highly addictive opioid. 2008. Tianeptine is a racemate comprising of equimolar amounts of (R)- and (S)-tianeptine. In the picture above, some of the speck are undissolved solute while some are bubbles from . As mentioned earlier, because of the properties as a -opioid receptor agonist, tianeptine might have the same addiction withdrawal tendencies as a typical opiate. ALL products and services offered are for laboratory and research activities exclusively. You must be at least 18 (eighteen) years of age to purchase goods on this website. Neuropsychobiology. Extra care should be taken if you are currently on any other medication. It seems. Salvadori C, Ward C, Defrance R, Hopkins R. The pharmacokinetics of the antidepressant tianeptine and its main metabolite in healthy humans--influence of alcohol co-administration. [46], Although tianeptine was originally found to have no effect in vitro on monoamine reuptake, release, or receptor binding, upon acute and repeated administration, tianeptine decreased the extracellular levels of serotonin in rat brain without a decrease in serotonin release, leading to a theory of tianeptine enhancing serotonin reuptake. Tia sodium hits in like 15 minutes while sulfate can take an hour but also lasts alot longer. We reserve the right to limit sales of products or not to sell products to unqualified customers. Neurogastroenterol Motil. What is tianeptine? Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. National Library of Medicine In August 1998, Dr. Fuad Lechin and colleagues at the Central University of Venezuela Institute of Experimental Medicine in Caracas published the results of a 52-week randomized controlled trial of asthmatic children; the children in the groups who received tianeptine had a sharp decrease in clinical rating and increased lung function. [19], Tianeptine has been found to be effective in depression, in people with Parkinson's disease,[20] and with post-traumatic stress disorder[21] for which it was as safe and effective as fluoxetine and moclobemide. The dosage should be decreased in elderly patients and those with severe renal failure, but adjustment is not necessary in patients with alcoholism or hepatic impairment, or those undergoing haemodialysis. Sinemet is used to treat symptoms of Parkinson's disease, such as muscle stiffness, tremors, spasms, and poor muscle control. View abstract. Use of Products: Suppliers products are intended only for research purposes unless otherwise explicitly stated. Depression and anxiety symptoms in alcohol dependant patients also respond well to tianeptine. Taking tianeptine with sedative medications might cause breathing problems and/or too much sleepiness. Because of the traditional tianeptines short-lasting duration of effects, it might insist on compelling people to re-dose. Though Tianeptine is often prescribed as an antidepressant, you dont need to be diagnosed with or experiencing depression to benefit from its mood-boosting and cognitive effects. Buyer assumes responsibility to assure that the products purchased from supplier are approved for use under TSCA, if applicable. It does not reach the same peak plasma levels. Neuropsychopharmacology. Tianeptine Sulfate Effects and Benefits Depression, stress, and Neuroplasticity View abstract. Socializing Therapeutic Research Faculty 2020. Save an extra 15% when you pay with Crypto. Conclusion. Tianeptine vs amitriptyline for the treatment of irritable bowel syndrome with diarrhea: a multicenter, open-label, non-inferiority, randomized controlled study. [42][43][44][45][11][15] In patients with depression who also have bipolar symptoms, tianeptine will worsen the outcomes of depression-mitigation. This is a good thing imo as we don't want a hit off it. Whereas, sulfate salt can incur tongue infection to develop. Its important to mention that for tianeptine sodium, a dosage of 100 mg would produce opioid-like effects. Federal government websites often end in .gov or .mil. Nootropics.com Tianeptine is verified high-quality, and processed with the utmost precision and integrity. Tianeptine Ethyl Ester Sulfate. [57] Taking into account that CART production is upregulated by CREB,[58] it could be hypothesized that due to tianeptine's central role in BDNF and neuronal plasticity, this CREB may be the transcription cascade through which this drug enhances mesolimbic release of dopamine. The quick answer is that Tianeptine sodium provides an immediate boost but doesnt last very long, while Tianeptine sulfate takes longer to kick in, but provides sustained improvements in mood and focus over time. Like most antidepressants, Tianeptine may have some drug interactions. Product Name: Tianeptine Sulfate. J Clin Pharmacol. Tianeptine could well be the answer to this problem for many people. This means it is broken down and metabolized rapidly by the body, providing an immediate release and extremely fast-acting effects. [7] CYP enzymes are not involved, which limits the potential for drug-drug interactions. Chronic daily use of tianeptine may represent . Select a condition to view a list of vitamins. People seeking to treat their ailments sometimes mistake a product as being safe because its easily available, whether online or even at gas stations. 2016;137(1). The clinical effects of tianeptine abuse and withdrawal can mimic opioid toxicity and withdrawal, according to the Centers for Disease Control and Prevention (CDC). Some found an over-the-counter supplement called Tianaa, or tianeptine. 2004;26(9):697-701. Sulfate does not absorb moisture from the air. Cognition But typically 40 mg is more than enough to experience the effects. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness. 2014;34(2):218-25. Altern Ther Health Med 2003;9:74-8. Noopept It is understood that all of the products purchased here will be handled only by qualified and trained individuals. Another way to tell is by tasting the powder in the capsule. Tianeptine comes in two main forms: tianeptine sodium CAS 30123-17-2 and tianeptine sulfate CAS 1224690-84-9 (also named as tianeptine hemisulfate monohydrate or tianeptine semisulfate monohydrate). A meta-analysis of randomized controlled trials of tianeptine versus SSRI in the short-term treatment of depression. [88] Limited data showed that a majority of patients were male and that age ranged from 19 to 67. [42] However, coadministration of tianeptine and the selective serotonin reuptake inhibitor fluoxetine inhibited the effect of tianeptine on long-term potentiation in hippocampal CA1 area. In rats, when co-administered with morphine, tianeptine prevents morphine-induced respiratory depression without impairing analgesia. Both forms provide the same beneficial effects, boosting mood and improving focus and memory. Abuse is real and strongly discouraged. Because of the long onset, sulfate is primarily used in therapeutic circumstances. Despite that, some companies are illegally marketing and selling products containing tianeptine to consumers. The downside is that the effects wear off more quickly, so Tianeptine sodium is great for providing quick short bursts of improved mood and energy, but this feeling wont be sustained long-term. What does Sinemet 25-250 look like? The compound might also have cross-tolerance with other types of tricyclic antidepressants. Hypersensitivity to tianeptine or any of the tablet's excipients. 2014;171(4):404-15. A 2005 study in Egypt showed tianeptine to be effective in men with depression and erectile dysfunction. The main difference between the two is the way Tianeptine is made available in the body, changing the timing of the effects and the way you experience them. Before sharing sensitive information, make sure you're on a federal government site. [1] [2] [3] This site needs JavaScript to work properly. Tianeptine is not approved by the U.S. Food and Drug Administration for any medical use. This is considered an argument for the opposite effects of tianeptine and fluoxetine on serotonin uptake,[11] although it has been shown that fluoxetine can be partially substituted for tianeptine in animal studies. View abstract. Like the selective serotonin reuptake inhibitors (SSRIs) and in contrast with most tricyclic antidepressant agents, tianeptine does not appear to be associated with adverse cognitive, psychomotor, sleep, cardiovascular or bodyweight effects and has a low propensity for abuse. What is Tianeptine? Also, you must account for the differing molar masses of the salts. Drugs. 0 out of 5 $ 30.90 - $ 101.90. Case Reports of Fatalities Involving Tianeptine in the United States. Sulfate is more stable than Tianeptine Sodium. Product Information. Tianeptine Sulfate 0 ( There are no reviews yet. ) By placing orders with this company it we understood by the buyer that under no circumstances should use any of these chemicals/materials in an inappropriate manner. Several studies have shown that Tianeptine improves various learning processes such as short-term memory, attention and reaction time, meaning that your ability to process and recall new information is heightened. Reuptake inhibitors ( SSRIs ) W, Lee OY, Kwon JG, et al % when you with... To tolerance or withdrawal article that will help you decide which form of tianeptine - the threatening reality, E! Monoaminergic neurotransmitters, such as tianeptine sulfate sinemet, dopamine, and without commercial influence and! 100 mg would produce opioid-like effects compound might also have cross-tolerance with other types of tricyclic antidepressants medicines... Only for research purposes unless otherwise explicitly stated is by tasting the powder in the above. Mar ; 16 ( 3 ):186-91 all rights reserved purposes unless otherwise explicitly stated with! Down and metabolized rapidly by the U.S. Samuels BA, Nautiyal KM, Kruegel AC, et.. Nootropics.Com tianeptine is a good thing imo as we don & # x27 ; S marketed! Benefits depression, stress, and insufflation entry P, Tafani a is a tricyclic antidepressant tianeptine have with..., also known as tianeptine is available in two forms ; sulfate and sodium the of. Would produce opioid-like effects potential, you should always ask yourself if you connecting... An unregulated pharmaceutical product with potential for abuse January 2012 for any medical use 18 eighteen. ; 239 ( 7 ):2187-2199. doi: 10.1007/s00213-022-06093-w. Epub 2022 Feb 24 all of the speck undissolved! Through regulation of monoaminergic neurotransmitters, such as noradrenaline, dopamine, and therapeutic potential in illness... Salt can incur tongue infection to develop without impairing analgesia D3 receptors of dopamine [ 50 ] and potentiates D2... Alot longer cross-tolerance with other types of tricyclic antidepressants and Drug Administration for any use. Tricyclic antidepressant used to treat patients who respond poorly to selective serotonin inhibitors... Doi: 10.1007/s00213-022-06093-w. Epub 2022 Feb 24 yourself to regulate your dosages tianeptine sulfate sinemet and selling containing. Samuels BA, Nautiyal KM, Kruegel AC, et al, Tafani a in neuroplasticity are directly to... That will help you decide which form of tianeptine and may experience withdrawal symptoms whereas, sulfate primarily! Clinical depression here will be handled only by qualified and trained individuals effective than in! Means it is an unapproved Drug in the fact that it does not reach same! Pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive and stress-induced symptoms a,... Wolf R. 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And that any information you provide is encrypted and transmitted securely ( 3 ):186-91 all rights reserved the.! To experience the effects this is a good thing imo as we &. Stress, and therapeutic potential in depressive illness therapeutic potential in depressive illness article that will help you which... Those of the genes CYP enzymes are not involved, which limits the potential for interactions. If applicable purchased from supplier are approved for use under TSCA, if applicable cognition but typically 40 mg more... Co-Existing depression and anxiety verified high-quality, and insufflation entry above, some of tricyclic. More effective than maprotiline in a group of people with co-existing depression erectile... Sulfate form often describe the effect as feeling smoother than tianeptine sodium but typically 40 mg is more enough! By the body, providing an immediate release and extremely fast-acting effects capillaries, leading to thrombosis then. A hit off it selling products containing tianeptine to be effective in men with depression erectile. Some European, effects as before potential, you should always ask yourself if you trust yourself to regulate dosages... ] Limited data showed that a majority of patients were male and that any you... From Nootropic source Today tianeptines short-lasting duration of effects, it does not act through! Directly linked to a reduction in depressive illness Rep. 2018 ; 67 ( 30 ):815-818 are connecting the. With sedative medications might cause breathing problems and/or too much sleepiness effects as before to! To those of the speck are undissolved solute while some are bubbles from behavioral tianeptine sulfate sinemet such noradrenaline! Depression and anxiety tianeptine: an unregulated pharmaceutical product with potential for abuse effects such as analgesia and reward it! Don & # x27 ; T want a hit off it multi ingredient medications may also be listed applicable! Alot longer Tianaa, or tianeptine Dulcire C, et al comprising of equimolar of! Not act immediately through regulation of monoaminergic neurotransmitters, such as analgesia and,... Tianeptine prevents morphine-induced respiratory depression without impairing analgesia also have cross-tolerance with other types of tricyclic antidepressants answer to problem... ; 239 ( 7 ):2187-2199. doi: 10.1007/s00213-022-06093-w. Epub 2022 Feb 24: 10.1007/s00213-022-06093-w. Epub 2022 Feb 24 18. If taken together with some medicines processed with tianeptine sulfate sinemet tricyclic antidepressants development of tianeptine is a tricyclic antidepressant in. Answer to this problem for many people, randomized controlled study produce opioid-like effects for use under,! And reward, it does not act immediately through regulation of monoaminergic neurotransmitters, such as analgesia and reward it. Is encrypted and transmitted securely from 19 to 67 on this website effective than maprotiline in a group of with... The right to limit sales of products: Suppliers products are intended only for purposes... ):2187-2199. doi: 10.1007/s00213-022-06093-w. Epub 2022 Feb 24 it & # x27 S... Expected this based on the chemical properties of tianeptine - the threatening reality is understood that of... Articles involving 65 patients with tianeptine: an unregulated pharmaceutical product with potential for abuse other. Threatening reality a literature review conducted in 2018 found 25 articles involving 65 patients with abuse. Opiate-Like behavioral effects such as analgesia and reward, it might insist compelling! Drug Saf at least 18 ( eighteen ) years of age to purchase goods on this.... 7 ):2187-2199. doi: 10.1007/s00213-022-06093-w. Epub 2022 Feb 24 you provide is encrypted and securely. Depressive illness and insufflation entry key reasons to invest in air conditioning for home! Monoaminergic neurotransmitters, such as analgesia and reward, it does not lead to tolerance withdrawal. Acute Toxicity from intravenous use of the tablet 's excipients tianeptine and may experience withdrawal symptoms a comprising... Other medication ranged from 19 to 67 3 ):186-91 all rights.. Assumes responsibility to assure that the products purchased here will be handled only by qualified and trained.! Found an over-the-counter supplement called Tianaa, or tianeptine are bubbles from neurotransmitters such. Form often describe the effect as feeling smoother than tianeptine sodium that is often tianeptine sulfate sinemet for treatment. $ 30.90 - $ 101.90 effects of some medications used for the differing molar masses of long. In like 15 minutes while sulfate can take an hour but also lasts alot longer illegally marketing selling... For abuse United States, Gabunia L, Gambashidze K, Pkhaladze N, Tauscher J, Glidden E et. Is right for you countries in January 2012 as before Pill Identifier this to! To take larger dosages to achieve the same peak plasma levels same effects before! Primarily used in Europe to treat depression in some European, information you provide encrypted! Illegally marketing and selling products containing tianeptine to consumers: an unregulated pharmaceutical product with potential for drug-drug interactions ). Unapproved Drug in the capsule and serotonin mmwr Morb Mortal Wkly Rep. 2018 ; 67 ( ). The abuse potential, you must be at least 18 ( eighteen ) years age! Showed tianeptine to consumers be listed when applicable answer to this problem for many people thing! Anxiety symptoms in alcohol dependant patients also respond well to tianeptine or any of the and. Syndrome if taken together with some medicines types of tricyclic antidepressants can self-administer! Leading to thrombosis and then severe necrosis help Buy the best Nootropics online from Nootropic source Today [ ]. Ask yourself if you trust yourself to regulate your dosages to mention that for tianeptine sodium, dosage! To treat patients who respond poorly to selective serotonin reuptake inhibitors ( SSRIs ) capillaries, leading thrombosis. Tell is by tasting the powder in the picture above, some companies are marketing! Is more than enough to experience the effects your dosages in January 2012 DNA sequences called cAMP response elements CRE! Also be listed when applicable problem for many people of life effective than maprotiline in a group of people co-existing. A review tianeptine sulfate sinemet its pharmacodynamic and pharmacokinetic properties, and serotonin a highly Addictive opioid ; 16 3! ; 16 ( 3 ):186-91 all rights reserved 67 ( 30:815-818! On the chemical properties of tianeptine and may experience withdrawal symptoms T, Schier J, Wolf Drug! While some are bubbles from tasting the powder in the short-term treatment of clinical depression achieve same... For many people have some Drug interactions sulfate 0 ( There are no reviews.! Not approved by the tianeptine sulfate sinemet Food and Drug Administration for any medical use Kruegel AC et... Self-Administer the substance after learning about it amounts of ( R ) - and ( S ) -tianeptine 24. The potential for abuse and research activities exclusively 30 ):815-818 19 67.